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Cardiac Muscle
Contraction-Relaxation
Function

Sarcometrics provides pre-clinical evaluation of candidate pharmaceuticals, compounds, proteins and peptides in cardiac muscle.

Functional Phenotype

Functional Phenotype

We deliver cardiac functional phenotype at the whole heart, myocardial tissue, and single myocyte levels.

Sarcometrics

Evaluate Myosin Kinetics within the Muscle

We evaluate myosin crossbridge detachment rate using mechanical perturbation methods in intact or skinned muscle preparations.

End-Systolic Elastance

End-Systolic Elastance

We mimic the pressure-volume relationship using force-feedback control of muscle length of cardiac slices. The cardiac slice allows for visualization of sarcomere length and direct evaluation of length-dependent activation and the Frank-Starling response.

Mimic Pressure-Volume Work Loops

Monitor Diastolic Sarcomere Length

Calcium Regulation

Mimic Pressure-Volume Work Loops

Calcium Regulation

Monitor Diastolic Sarcomere Length

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Sarcometrics, LLC
Burlington, VT

[email protected]
[email protected]

802-324-3764

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